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Life Extension

Life Extension CR Mimetic Longevity Formula


60 vegecaps

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Life Extension CR Mimetic Longevity Formula is a unique combination of antioxidants to help support healthy metabolic function. Life Extension has gone to extraordinary lengths to identify those compounds that simulate calorie restriction's ability to trigger youthful gene expression — the process by which genes transmit signals that slow certain aspects of aging. In 2003, we introduced standardized extract of resveratrol. In 2009, we introduced the other resveratrol, pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your longevity genes.

We've brought together the five known calorie restriction mimetics … trans-resveratrol, trans-pterostilbene, quercetin, grape seed polyphenols, and black tea extract in one, high potency formula. And to that we've now added a sixth to formulate CR Mimetic!

This innovative formulation features the little-known flavonoid fisetin (which is most abundantly found in strawberries). It is the sixth compound shown to simulate a youthful gene expression pattern similar to calorie restriction without significant dietary modification.

Fisetin may also enhance the effects of resveratrol. Researchers have uncovered compelling evidence of fisetin's ability to stabilize resveratrol by shielding it from metabolic breakdown… thus extending its effects.

Fisetin has been shown to have the power to switch on powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function. Fisetin also supports aging neurons in the presence of oxidative stress.

And each serving of CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction's favorable influence on your longevity genes.

This unique formula provides cutting-edge broad-spectrum support for youthful gene expression from the most scientifically validated, natural sources.


Take two capsules daily with or without food, or as recommended by a healthcare practitioner.

Can be taken together or in divided doses.

This product should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.


Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anticoagulant, antiplatelet, or diabetic medications.

Each Vegecap Provides:

Trans-Resveratrol [from Polygonum cuspidatum extract (root)] 250mg
Trans-Pterostilbene (as pure Pterospan and SMART pterostilbene) 3mg
Quercetin (as quercetin dihydrate) 150mg
Masquelier’s Original OPCs [single and condensed (2-5) units of flavanols & polyphenols from Vitis vinifera (grape) seeds] 50mg
Black tea decaffeinated (Camellia sinensis) extract (leaf) [standardized to 12% TF2a theaflavin fraction (36 mg), along with TF1, TF2b and TF3 theaflavin fractions] 300mg
Fisetin [from (Rhus succedanea L.) extract (stem)] 48mg

Also contains: Vegetable cellulose (capsule), stearic acid, silica.

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Life Extension

The Life Extension Foundation is the world’s largest membership organization dedicated to investigating every method of extending the healthy human life span and funding anti-aging research. Based on current scientific research, Life Extension is continually formulating and upgrading its science-based multivitamin, vitamin, and nutritional supplement formulas to include the latest novel ingredients that are years ahead of mainstream offerings.

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My husband reserched this product widely and the evidence pointed to the efficacy of this product. We have been taking it for some time and believe that, in addition to what may be our own genetic composition, it has maintained us at a level of health and well being that does not reflect our advanced years. I would recommend this product.

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Product Highlights

  • Helps support healthy metabolic function



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    If you have changed your mind about a product and it is in re-saleable condition (unopened, with undamaged packaging) you can return it within 30 days of receipt for a full refund.

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