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Nature's Sunshine


30 tablets
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Product Specialties
GMP Manufactured
Good Ingredients Approved
Heavy Metals Tested
Synthetic Preservative Free
GMO Free
Artificial Sweetener Free
Artificial Flavour Free
Artificial Colour Free
Alcohol Free
Dairy Free
Sugar Free
Soy Free
Nut Free
Gluten Free
Egg Free
Recyclable Packaging
BPA-Free Packaging
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Mindful Brands
Mindful Brand Nature's Sunshine is a Mindful Brand. They’re committed to meaningful change that looks after our people and planet. Learn more
Nature's Sunshine SAM-e (S-Adenosyl-methionine tosylate) is a naturally occurring amino acid found throughout the body with high concentrations in the adrenal glands, liver and brain. It is required in over 40 biochemical reactions, helping with a variety of functions, including mood regulation, cognitive function, general nerve conditions, liver and heart health. 

Most of the body's SAM-e is synthesised in the liver from the amino acid methionine, with the help of folic acid and vitamin B12. SAM-e's primary role is supporting healthy levels of serotonin, an important neurotransmitter in the brain known for supporting mood balance. 

Scientific studies show SAM-e naturally supports mood balance in as little as 7 to 14 days when taken daily. 

SAM-e provides a source of sulfur, an important compound used to support healthy cartilage and strong joints and for synthesis of taurine and glutathione, used in liver detoxification processes. Factors such as age, certain health conditions and poor diet can impact the amount of SAM-e found in the body. It also appears to help fight premature aging by regenerating new cells, especially in joint and liver tissue. 

Nature's Sunshine's SAM-e contains 200mg of pure S-Adenosylmethionine tosylate disulfate in each enteric coated tablet. The enteric coating prevents SAM-e from prematurely breaking down in the bottle and also provides for optimal absorption of SAM-e in the small intestine. 


  • If you are taking prescription antidepressants or have bipolar (manic) depression, consult your physician before or during the use of this product. 
  • Pregnant or lactating women should consult their health care provider prior to taking this supplement.
Take: 2 tablets once or twice daily on an empty stomach with a glass of water.

Refrigerate after opening.
For best results, take SAM-e  with folic acid and Vitamin B12.
Per 2 tablets:

S-Adenosylmethionine (from S-Adenosyl-L-methionine tosylate Disulfate) 400mg

Also contains: S-Adenosyl-L-methionine disulfate p-toluensulronate, Microcrystalline cellulose, Magnesium hydroxide, Stearic acid, Magnesium stearate, Colloidal silica anhydrous, Calcium oxide Coating (Talc, Flake shellac dewaxed, Arginine base, Glycerol, Magnesium stearate, Collodial silica anhydrous, Sodium alginate).

  • Supports mood, emotional well-being 
  • Supports the nervous system 
  • Energy & vitality 
  • Cognitive function 
  • Joint health & mobility

Nature's Sunshine SAM-e Review