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SAM-e Supplement

SAM-e (S-Adenosyl methionine) is an amino acid derivative needed by the body for at least 40 biochemical reactions. It has a reputation as one the most effective natural anti-depressants, supporting a positive outlook without any of the unpleasant side effects of prescription drugs.

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SAM-e Info

SAM-e (S-Adenosyl methionine) is an amino acid derivative needed by the body for at least 40 biochemical reactions. It has a reputation as the most effective natural anti-depressant, without any of the unpleasant side effects of prescription drugs. It was first discovered in 1952 in Italy, and naturally occurs throughout the body when you are in good health. Aging processes, nutrient deficiency, sickness and depression can deplete SAM-e levels, indicating a need for supplementation.

SAM-e Benefits

SAM-e is involved in the manufacture of hormones, cell membranes and mood regulating neurotransmitters. It is a potent mood elevator, energy enhancer, promoter of cell regeneration, neuromuscular balancer and joint mobiliser. It helps maintain cartilage and may support prevention and repair of liver damage.

Studies show SAM-e may be effective in treating depression, fibromyalgia, joint pain, osteoarthritis, liver dysfunction and migraines.

SAM-e is best taken alongside a vitamin B complex to maximise efficacy and prevent side effects.

SAM-e Side Effects

Contraindicated when taking MAOI antidepressant medications. Contraindicated in cases of bipolar disorder unless under close medical supervision as it may promote the manic phase. Contraindicated in Parkinson’s disease as it may aggravate some symptoms. Possible side effects include gastrointestinal upsets: nausea, vomiting, diarrhoea, indigestion. Anxiety, headache, insomnia and allergies may also be experienced.

Product Reviews

  • Glad I found this product


    SAM-e was recommended to me by a friend and I am so glad it was. I was having trouble dealing with the 'electric' feeling you get pulsing through your body when you feel anxious, and it helped take that horrible feeling away. When I get that feeling I can't control, it soothes you internally so you can think more rationally. I don't take the recommended 10 drops and it still works fine for me. Will definitely buy more when I run out.



  • Helpful, but possibly not for everyone


    I started taking this SAM-e product to help with fibromyalgia and mild depression. The recommended dose on the bottle of 10 drops twice a day, made me quite anxious, and nauseous, and caused quite painful stomach cramps. It did however significantly help reduce my nerve pain, and I do feel more motivated and less overwhelmed by life in general. With some experimentation, I now take 5 drops a day with food, and a b vitamin complex. This dose seems to be quite effective for me, but without the side effects I had on the higher dose.



  • found at last...


    This product is prescribed in the UK for Arthritic conditions as well as depression. As I was losing sleep over the aches and pains of osteoarthritis and pain killers do not suit I am pleased to say this Sam-ee really helps have a more restful sleep, resulting in feeling more refreshed, also clearer in the head:)



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