I've used these for 4 years or so now. My anxiety (and related energy level problems) was very high, so I took 2-3 capsules at a time to notice any effects. Effects were not as significant as I expected, but I think that's because my anxiety level was just so extreme, and I'm sure I had other intestine issues affecting my state of mind too. It still had the most decent effect out of everything I had tried for immediate relief, so remains a regular part of my daily supplement and nutrition plan. Thanks to a holistic plan my anxiety levels are a lot lower now, but when occasionally, I let it run out for more than a week I have noticed a definite difference in my anxiety levels - an edgy, hyper-alert feeling emerges and before I know it I realise my anxiety has increased. Overall I can recommend it as an immediate anxiety-reliever, as well as for taking for long-term maintenance of anxiety levels.